A new study conducted on mice by scientists from University of California, San Francisco (UCFS) has identified that an extract derived from bone marrow cells can effectively improve cardiac function after heart attack as bone marrow stem cells does accordingly.
Both the stem cell and cell extract therapies resulted in the presence of more blood vessels and less cardiac cell death, or apoptosis, than no therapy. The findings were published online and in the July 2009 issue of the Journal of Molecular Therapy.
The study also showed that heart function and formation of scar tissue benefited despite the finding that few of the injected cells remained in the heart at one month after therapy.
According to Yerem Yeghiazarians, MD, study author, cardiologist and director of UCSF’s Translational Cardiac Stem Cell Development Program, there is always a general believe that that stem cell therapy with these cells results in some level of functional improvement after a heart attack, though the exact mechanism is not clear, and supporting that issue the Peer-reviewed medical literature is controversial as to whether bone marrow cells differentiate into cardiomyocytes, or cardiac muscle cells.
But the new results confirm that whole cells transplant could be avoided in order to see the beneficial effects of bone marrow cell therapy.
Yeghiazarians also added that current therapies can improve symptoms but do not replace scar tissue. Scientists looking forward to use stem cells to decrease the scar, minimize the loss of cardiac muscle and maintain or even improve the cardiac function after a heart attack.
Researchers are investigating these new therapies to improve cardiac function after heart attack in an effort to prevent heart failure.
The researchers are conducting further studies to evaluate bone marrow cell and extract therapies in order to identify the proteins and factors within the extract and gain insight into the possible mechanisms of cardiac functional improvement.
Source : ScienceDaily