Mascular-distrophyResearchers from University of Birmingham, UK, claimed that they have able to identified key factors that could hopefully presume the chances of Mascular Dystrophy (DM) at the most primary stage.

Muscular dystrophy is such a disease where patients can benefit from early treatment.

Muscular dystrophy is the name given to a group of diseases that cause muscles to waste and weaken.

Researchers used mice as model animals to study the key proteins involved in two types of muscular dystrophy (MD): the most severe MD form, Duchenne Muscular Dystrophy (DMD), and a more mild form, Limb Girdle MD (LGMD-1c).

This study demonstrates that there are prenatal signs for muscular dystrophy, and suggests that both types of MD might be detected in utero or shortly after birth.

The study finds Muscle fibres are created when stem cells line up and fuse together, forming a long thin tube, called a myotube. In healthy people, bundles of myotubes align in the same direction, allowing muscles to contract efficiently.

Researchers found disrupted stem cell function and delays of skeletal muscle formation in embryos of MD-like mice.

In muscular dystrophy the myotubes do not align properly, resulting in muscle fibres becoming uneven and malformed.

Lead researcher Smith and colleagues found 8% to 16% of the tubes in a bundle were pointing in the wrong direction.

Experts believe that this findings can offer a better quality of life for children suffering from MD, as it is now clear that early treatment significantly improves life expectancy and quality of life for MD children.

For further information regarding the study see report published in Disease Models & Mechanisms (DMM), dmm.biologists.org,

Source: ScienceDaily