Franch researchers claimed to have successful in use of stem cell therapy to myeloid sarcoma. Myeloid sarcoma in an accumulation of myeloblasts in tissues outside the bone marrow in patients with acute myeloid leukemia (AML). Myeloid sarcoma can occur prior to, concomitant with or after the diagnosis of AML.
Researchers involved in the current study reported the outcomes of 51 patients with myeloid sarcoma treated with an allogeneic stem cell transplant. The average age of the entire group was 29 years (2.2-53) and 14 of the patients were children. Six patients had an isolated myeloid sarcoma without evidence of AML, 19 had simultaneous AML and myeloid sarcoma, and 26 has a previous history of AML. Forty of the 51 patients had only a single site of disease.
Twenty-one patients were in first remission of AML and the remainder had more advanced disease. Thirty patients received stem cells from related donors and 21 from unrelated donors. Thirty-one patients received conditioning regimens containing total-body irradiation. The median time from diagnosis of AML to transplant was 8 months. Median follow-up was 33 months.