stem-cell-genesAs per Science Daily its a stem cell surprise, and its being such a surprise that would divert the whole global stem cell thoughts and would overturn the previous stem cell researches.

Scientists at the Carnegie Institution’s Department of Embryology, have identified this stem cell surprise that would turned down the previous research that identified critical genes for making muscle stem cells. and would challenge the research which uses stem cells for healing tissues.

Lead researcher Christoph Lepper, a predoctoral fellow in Carnegie’s Chen-Ming Fan’s lab and a Johns Hopkins student have identified¬† that after suppressing the essential embryonic and neonatal muscle stem cells genes,Pax3 and Pax7¬† in adult muscle stem cells, they were really suprised to find that the muscles stem cells are normal without them.

Researchers also injured the leg muscles between the knee and ankle of mice, and once again suprised to find that these muscle stem cells, without the two key embryonic muscle stem cell genes, could generate muscles as well as normal muscle stem cells. They repeat the process and found that the stem cells were still active.

Scientists assume on the basis of their findings that :

  • these embryonic genes are important to muscle stem cell creation up to the first three weeks after birth.
  • these two embryonic muscle stem cell genes also tell the stem cells to become quiet as the organism matures.
  • After the time is reached, they “hand over” their jobs to a different set of genes.

Scientist are eagerly looking forward to find out the new set of genes that activate the adult stem cells at the time of injury.

The study is published in the June 25 advance online edition of Nature, and funded by the Carnegie Institution, NIH, and the Riley Children’s Foundation.

Source: EurekAlert, ScienceDaily