One of the country’s leading stem cell biologists, Haifan Lin, has been appointed director of the Yale Stem Cell Program effective September 1, Yale School of Medicine Dean Robert Alpern announced this week.一個國家的領導幹細胞生物學家,海帆林,已被任命為主任的耶魯大學幹細胞程序有效九月一日起,耶魯大學醫學院的院長羅伯特alpern本週宣布。

Lin, currently a cell biology professor and co-director and co-founder of the Duke (University) Stem Cell Research Program, will oversee a group of a half-dozen scientists devoted to research into fundamental aspects of stem cell biology.林,目前細胞生物學教授和合作,董事及共同創辦人公爵(大學)幹細胞研究計劃,將監督的一組半打以上的科學家致力於研究納入基本方面,幹細胞生物學。 Areas of research will include the properties and mechanisms of human embryonic stem cells, human adult stem cells, and stem cells in model organisms such as mouse, fruit fly and nematode.研究領域將包括性能及機理研究人類胚胎幹細胞,人類成體幹細胞,幹細胞的模式生物,如老鼠,果蠅和線蟲。 The program will bring together more than 30 additional faculty members across the medical school and university who are working on stem cell-related topics.該計劃將匯集30多個額外的學院成員在整個醫療學校和大學的人士,工作就幹細胞有關的議題。

Lin’s research has greatly strengthened understanding of the molecular mechanisms that define the unique behavior of stem cells.林的研究,大大加強了了解的分子機制,界定獨特的行為的幹細胞。 His early contributions include identification of stem cells in the Drosophila ovary and establishment of these stem cells as an effective model for study.他早年的貢獻,包括查明幹細胞在果蠅的卵巢和建立這些幹細胞作為一種有效的模型進行研究。 Using this model, Lin obtained direct evidence for the century-old hypothesis for “asymmetric division” of stem cells, which allows them both to self-renew and to produce differentiated daughter cells.利用該模型,林取得直接證據,為百年歷史的假說為“非對稱分化”的幹細胞,這使得他們既要自我更新和產生分化的子細胞。

He was also the first to identify and name “niche signaling cells” in the fly model and has been a key player in systematically demonstrating the longstanding “stem cell niche theory” on the essential role of microenvironment signaling in stem cells self-renewal.他亦是第一次,以確定和命名為“利基細胞信號: ”在飛行模型,並已成為關鍵角色,系統地展示了源遠流長的“幹細胞小生境論”的重要作用,微信號在幹細胞自我更新。 In the process, Lin discovered key genes involved in both niche signaling and intracellular regulation of stem cell division.在這個過程中,林發現關鍵基因所涉及的兩個利基信令和內規例幹細胞記名表決。

The Yale Stem Cell Program will grow over the next few years with the recruitment of four additional faculty members and an administrative and technical staff.耶魯大學幹細胞項目將不斷增加,未來數年內,與招聘增設四個學院的成員和一名行政人員和技術人員。 Three initial core facilities are planned: a human embryonic stem cell culture core laboratory directed by Lin and Krause; a cell sorting core directed by Mark Shlomchik, MD, professor of laboratory medicine and immunobiology, and a confocal microscopy core directed by Michael Nathanson, MD, professor of medicine and cell biology. 3初步核心設施計劃:人類胚胎幹細胞培養的核心實驗室的指示,林和克勞斯;細胞分選技術為核心的導演馬克shlomchik ,醫學博士,教授,醫學檢驗和immunobiology ,以及共焦顯微鏡為核心的導演邁克爾內桑森,醫學博士,醫學教授和細胞生物學。

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