Vanderbilt University Medical Center is the first in the state to perform a novel therapy that uses bone marrow stem cells to stimulate regeneration of the heart muscle after a heart attack.

Vanderbilt is one of three medical centers in the country providing this new treatment modality as part of a multi-center, randomized study funded by Amorcyte, a privately funded cell-therapy company studying stem cells for the treatment of cardiovascular disease.

Physicians are excited about the prospects of this therapy because of the enormous potential to transform the way they treat people with cardiac disease, says Douglas Vaughan, M.D., chief of the Division of Cardiovascular Medicine.
This is the first patient of many that they will enroll in their randomized-controlled trials to study the effects of cell therapy in treating cardiac disease.

John Plummer, 63, underwent the stem cell regeneration therapy on March 11, about one week after experiencing a heart attack.

“There are no guarantees,” said Plummer. “It was the prospect of improvement — any improvement — that made it worth it. There are certain risks, but the prospect of the study proving to be valuable to others as well, all of those considerations made it seem like something I ought to do.

Plummer, an English professor for 36 years at Vanderbilt University, is not the first patient tested for eligibility into the trial. More than 100 patients have been screened, but did not meet the criteria for study participation – impaired heart function after an acute heart attack.

“If we treat a patient rapidly, some may not have any damage at all,” said David Zhao, M.D., director of the Cardiac Cath Lab. “But for those who, despite all efforts, suffer damage to the heart muscle, we are studying the effects of this treatment in repairing the heart muscle.

“We are hoping that this is just the beginning of the journey and eventually we will be able to provide this unique therapy as part of our treatment protocol to patients with a damaged heart.”

Vanderbilt’s participation in this Phase I, industry-supported study highlights its role as a key player in stem cell regeneration in this country. For years, Europe has been the site for much of the heart-related, stem cell based therapies.

“Fewer than five centers in the country are doing this kind of cell-based therapy,” said Zhao. “Coupled with the fact that we are one of five programs funded by the NIH for cell-based therapies definitely brings Vanderbilt to the next level. We are playing a leading role in cell therapy.”

Patients enrolled in the Amorcyte trial, like Plummer, will be seen regularly for up to five years. Within three to six months, investigators expect to see some improvement in heart function.

“This treatment approach looks very promising based on preliminary results already published,” said Friedrich Schuening, M.D., chief of the Section of Hematology and Stem Cell Transplant. “The study would not have been possible without the excellent collaboration between our colleagues from the Division of Cardiovascular Medicine and from the Vanderbilt Stem Cell Transplant Program.

Patients qualifying for enrollment will be given a series of tests. Half the patients will be admitted into the standard treatment arm of the study, while the other half will receive an intra-coronary stem cell infusion. Bone marrow will be collected from the patient by a team at Vanderbilt and shipped to Amorcyte, where the stem cells will be processed. Within 24 hours, the cells will be returned to Vanderbilt and infused into the patient via a catheter directly into the coronary artery, where the cells will diffuse into the heart muscle.

Source:Vanderbilt University Medical Center, Dated March 16, 2007.