Neural Stem Cells Established from Adult Brain神經幹細胞的成立,從成人腦
According to SM Pollard and colleagues at the University of Edinburgh, they have recently reported the generation of adherent, symmetrically expandable, neural stem (NS) cell lines derived both from mouse and human embryonic stem cells and from fetal forebrain.據SM Pollard和和他的同事在英國愛丁堡大學,他們最近的報導,產生粘連,對稱膨脹,神經幹( NS )的細胞株衍生無論從小鼠和人胚胎幹細胞和從胎兒forebrain 。
These NS cells retain neuronal and glial differentiation potential after prolonged passaging and are transplantable.這些保留的NS細胞神經元和膠質細胞分化潛能的經過長時間的傳代和移植。 NS cells are likely to comprise the resident stem cell population within heterogeneous neurosphere cultures.生理鹽水細胞很可能包括駐地幹細胞的人口異質文化的神經。
Stable in vitro propagation of central nervous system (CNS) stem cells would offer expanded opportunities to dissect basic molecular, cellular, and developmental processes and to model neurodegenerative disease.穩定的離體繁殖的中樞神經系統( CNS )幹細胞將提供擴大的機會,以解剖的基本分子,細胞,以及發展過程和模型的神經變性疾病。
“CNS stem cells could also provide a source of material for drug discovery assays and cell replacement therapies”, wrote investigators in the journal Cerebral Cortex. “中樞神經系統的幹細胞也可以提供一個來源,材料藥物發現檢測和細胞替代療法” ,寫了調查,在雜誌大腦皮質。
Researchers have demonstrate that similar NS cell cultures can be established from the adult mouse brain.研究表明,類似的NS細胞培養可以建立由成年小鼠大腦。 They also characterize the growth factor requirements for NS cell derivation and self-renewal.他們還表徵生長因子要求的NS細胞的推導與自我更新。
Pollard and colleagues published their study in Cerebral Cortex (Adherent neural stem (NS) cells from fetal and adult forebrain. Cereb Cortex, 2006;16(Suppl. 1):I112-I120).波拉德和他的同事發表他們的研究在大腦皮質(粘附神經幹( NS )的細胞從胎兒和成人forebrain 。 cereb皮層, 2006 ; 16 (補編1 ) : i112 - i120 ) 。
For additional information, contact SM Pollard, University of Edinburgh, School Biology Science, Institute Stem Cell Research, Center Development Stem Cell Biology, Kings Bldg, Edinburgh EH9 3JQ, Midlothian, Scotland.如需詳細資訊,聯繫SM Pollard和,愛丁堡大學,中學生物科學研究所,幹細胞研究中心,發展幹細胞生物學,國王大廈,愛丁堡eh9 3jq , midlothian ,蘇格蘭。
The publisher’s contact information for the journal Cerebral Cortex is: Oxford University Press Inc., Journals Dept., 2001 Evans Rd., Cary, NC 27513, USA.出版者的聯繫信息雜誌大腦皮質是:牛津大學出版社公司,期刊部, 2001年埃文斯路,卡里,北卡羅來納州27513 ,美國。
































