Gene keeps neural cells on correct developmental path基因不斷神經細胞的正確的發展道路
Embryonic stem cells with identical genomes grow into distinctive tissues, such as heart, bone, and brain.胚胎幹細胞具有相同的基因組發展成為獨特的組織，如心髒病，骨和腦。 At one time, scientists believed the differences among cell types arose from various sets of genes switched on inside developing cells.在同一時間，科學家相信，彼此的差異類型的細胞產生的各套基因的開關對細胞內的發展。 Then, studies showed that adult neurons uniquely lack a protein that permanently turns off neuronal genes in the rest of the body’s cells.然後，研究表明，成人的神經元非常缺乏的蛋白質，永久關閉神經元基因在其餘的人體細胞。
Now, it turns out that precursor nerve cells contain that same repressive protein after all.現在，事實證明，前體的神經細胞含有相同的鎮壓蛋白後，所有。 In fact, the protein directs the complex network of genes that transforms an embryonic stem cell into a mature nerve cell, say Howard Hughes Medical Institute (HHMI) researchers.事實上，在蛋白質指示複雜的網絡，基因轉化胚胎幹細胞變成一個成熟的神經細胞，說霍華德休斯醫學研究所（ hhmi ）研究員。
“A single protein does it all,” said Gail Mandel, HHMI investigator at the State University of New York at Stony Brook. “一個單一的蛋白質是否所有，說： ”蓋爾曼德爾， hhmi調查人員在紐約州立大學石溪分校。 “It keeps the genes totally off in non-neuronal tissues, such as skin, where you don’t dare express a neuronal gene. “它不斷的基因完全關閉，在非神經組織，如皮膚，如果你不不敢表達神經元的基因。 But it also allows the full elaboration of the neuronal phenotype from the precursor cell.”但它也允許充分擬訂神經元表型，從細胞前體“ 。
